It is time to start a new project in Cites: Skylines. The map I use is Two Rivers. The base of this city is a square grid. Each block becomes 3×3 units and gets an internal access structure. See the example below. With this set-up,
the number of crossings remains low without inefficient use of space.
At the same time there are no short lanes between the crossings, which is good for the traffic flow: a lot of traffic can continue when the traffic light turns green. To be continued.

Grid example